Clinical effectiveness of 4% tetrasodium EDTA as a routine non-antibiotic antimicrobial lock solution in central venous access devices of hemodialysis and TPN patients against the TripleThreat™: An 18-month Canadian experience
Bibliographic record
Abstract
Introduction: The ideal catheter lock solution should be able to prevent the occurrence of the TripleThreatu2122 of clot, bacterial colonisation and biofilm formation. Providing an effective barrier for the inside of central venous access devices (CVADs) must be part of the multimodal approach to decrease the risk of catheter related complications such as catheter related bloodstream infections (CRBSI) and occlusions. However, this lock solution should not contribute to increasing the risk of antimicrobial resistance (AMR) and/or bleeding episodes. The in vitro effectiveness of a novel non-antibiotic antimicrobial solution of 4% tetrasodium EDTA was confirmed against biofilms formed by clinically relevant bacteria and fungi. The anticoagulant property of EDTA is well known and trusted. Therefore, the objective was to collect post approval safety and efficacy data from the use of this catheter lock solution in Canadian patients compared to the standard of care.Methods: Hemodialysis and TPN patients with CVADs were selected across Canada according to their high risk of CRBSI and alteplase use. Results: Canadian data collected over the last 18 months show both a clinically relevant decrease in CRBSI and alteplase use when the standard lock solution was replaced by 4% tetrasodium EDTA. The most frequent use of this lock solution was once a day in TPN patients with no safety concerns. Hypocalcemia was not observed with its use over time. Discussion and Conclusion: Results highlight the ability of 4% tetrasodium EDTA to reduce bacterial burden and biofilms in CVADs as well as providing well-established anticoagulant activities. Its multiple modes of action should prevent resistance from arising, protecting against catheter colonization and subsequent CRBSI, in patients with CVADs independent of medical condition. Tetrasodium EDTA is a safe and effective non-antibiotic antimicrobial lock solution in a time when the threat of AMR u201csuperbugsu201d is real and increasing.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".