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Record W4220815453 · doi:10.1089/end.2021.0956

Factors Associated with Stent Change and Prognosis in Patients with Malignant Ureteral Obstruction

2022· article· en· W4220815453 on OpenAlexaff
Shreyas Gandhi, Alex Koziarz, Antonio Finelli, Neil Fleshner, Robert J. Hamilton, Girish S. Kulkarni, Nathan Perlis, Alexandre R. Zlotta, Katherine Lajkosz, Jason Y. Lee

Bibliographic record

VenueJournal of Endourology · 2022
Typearticle
Languageen
FieldMedicine
TopicUreteral procedures and complications
Canadian institutionsPrincess Margaret Cancer CentreUniversity of TorontoUniversity Health Network
Fundersnot available
KeywordsMedicineStentHazard ratioSurgeryRetrospective cohort studyUreterCohortConfidence intervalMalignancyProportional hazards modelInternal medicine

Abstract

fetched live from OpenAlex

Purpose: To identify factors associated with stent changes and prognosis in patients with malignant ureteral obstruction (MUO) undergoing de novo retrograde ureteral stenting. Materials and Methods: A retrospective cohort study was conducted at a tertiary referral center for consecutive MUO patients referred and initially managed with a ureteral stent. Multivariable regression models evaluated factors associated with the following outcomes: number of stent changes, time to first stent change, and overall survival. Results: A total of 120 patients from May 2009 to December 2019 were included; mean age was 63 years, majority (76.7%) were women, median duration of follow-up was 6.1 months. Majority (75%) of patients did not require a stent change at 3 months follow-up. Patients with a history of pelvic radiation (subdistribution hazard rate [sHR] 2.12, 95% confidence interval [CI] 1.23–3.67, p = 0.007) and with a history of bowel resection (sHR 2.06, 95% CI 1.05–4.03, p = 0.036) were independently associated with earlier stent changes. Patients with gastrointestinal (GI) malignancy (hazard rate [HR] 14.1, 95% CI 2.66–74.19, p = 0.0019) and proximal ureter obstruction (HR 2.49, 95% CI 1.21–5.14, p = 0.0136) were associated with higher rate of all-cause mortality. Conclusions: The majority of patients did not require stent change at their first stent surveillance cystoscopy at 3 months follow-up. Patients with a history of pelvic radiation or bowel resection were more likely to require stent change during their stent surveillance visits. GI malignancy and proximal ureter obstruction were associated with higher rates of mortality.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.182

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.242
Teacher spread0.188 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2022
Admission routes1
Has abstractyes

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