CIRCADIAN DISRUPTION AS A FACTOR OF IMPAIRED ADAPTIVE T-CELL IMMUNITY RESPONSE
Bibliographic record
Abstract
The study was carried out with the aim to evaluate the effects of continuous lightning (CL) and subsequent circadian rhythm disruption on CD4+/CD8+ populations of adaptive cell immunity. For further understanding of underlying processes that affect CD4+/CD8+ proliferation and differentiation, the expression levels of CD3+ and CD95+ cell receptors were evaluated. Chinchilla rabbits were exposed to shift work simulation - 24 hours of CL. We organized 5 time-related groups: 2, 4, 6, 12 months of CL respectively. The 5th group – corresponding control. Thymus derived slides were examined using immunofluorescence assay. A decrease in the expression of CD3+ and CD8+ and an increase in the expression of CD4+ lymphocytes, which was accompanied by an increase in the ratio of CD4+/CD8+ were found after 2 months of the experiment. After 4 and 6 months of CL, there was an increase in CD3+ expression and a decrease in CD4+ and CD8+ expression. The lowest levels of CD3+, CD4+ and CD8+ were recorded after 12 months of the experiment, which is a manifestation of significant immunosuppression due to premature aging of the thymus. The level of CD95+ lymphocytes was higher in the group after 12 months of CL, indicating the activation of apoptosis in thymocytes caused by circadian rhythms disruption under the influence of chronic light stress.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".