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Record W4221115750 · doi:10.1038/s41598-022-06681-y

Metadata analysis indicates biased estimation of genetic parameters and gains using conventional pedigree information instead of genomic-based approaches in tree breeding

2022· article· en· W4221115750 on OpenAlexafffund
Jean Beaulieu, P. Lenz, Jean Bousquet

Bibliographic record

VenueScientific Reports · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic and phenotypic traits in livestock
Canadian institutionsCanadian Wood CouncilNatural Resources CanadaUniversité Laval
FundersGénome QuébecGenome CanadaNatural Resources CanadaGenome British ColumbiaUniversité LavalNorth Carolina State University
KeywordsHeritabilityBiologyImputation (statistics)Genetic gainSelection (genetic algorithm)StatisticsComputer scienceGeneticsGenetic variationMathematicsMissing dataMachine learningGene

Abstract

fetched live from OpenAlex

Forest tree improvement helps provide adapted planting stock to ensure growth productivity, fibre quality and carbon sequestration through reforestation and afforestation activities. However, there is increasing doubt that conventional pedigree provides the most accurate estimates for selection and prediction of performance of improved planting stock. When the additive genetic relationships among relatives is estimated using pedigree information, it is not possible to take account of Mendelian sampling due to the random segregation of parental alleles. The use of DNA markers distributed genome-wide (multi-locus genotypes) makes it possible to estimate the realized additive genomic relationships, which takes account of the Mendelian sampling and possible pedigree errors. We reviewed a series of papers on conifer and broadleaf tree species in which both pedigree-based and marker-based estimates of genetic parameters have been reported. Using metadata analyses, we show that for heritability and genetic gains, the estimates obtained using only the pedigree information are generally biased upward compared to those obtained using DNA markers distributed genome-wide, and that genotype-by-environment (GxE) interaction can be underestimated for low to moderate heritability traits. As high-throughput genotyping becomes economically affordable, we recommend expanding the use of genomic selection to obtain more accurate estimates of genetic parameters and gains.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.009
metaresearch head score (Gemma)0.023
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.991
Threshold uncertainty score0.047

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0090.023
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0030.004
Science and technology studies0.0000.001
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.260
Teacher spread0.206 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designMeta-analysis
DomainMethods
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2022
Admission routes2
Has abstractyes

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