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Genetic variants associated with longitudinal changes in brain structure across the lifespan
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
Bibliographic record
VenueNature Neuroscience · 2022
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsUniversité de MontréalCentre Hospitalier Universitaire Sainte-Justine
FundersCilagFP7 HealthFP7 Ideas: European Research CouncilNational Institute of Biomedical Imaging and BioengineeringNational Institute of Mental HealthNational Institute on Alcohol Abuse and AlcoholismEuropean Regional Development FundInstituto de Salud Carlos IIIComisión Nacional de Investigación Científica y TecnológicaNational Health and Medical Research CouncilBiotechnology and Biological Sciences Research CouncilMedical Research CouncilHorizon 2020 Framework ProgrammeGenentechNational Institutes of HealthMax Planck Instituut voor PsycholinguïstiekAvera Institute for Human GeneticsHeinz Nixdorf StiftungInstituto de Investigación Marqués de ValdecillaUK Dementia Research InstituteVetenskapsrådetNeuraxpharmFondation LeducqMission Interministérielle de Lutte Contre les Drogues et les Conduites AddictivesRoyal SocietyStichting Vrienden van het SophiaDiamantina Institute, University of QueenslandBergens ForskningsstiftelseUniversity of New South WalesRadboud Universitair Medisch CentrumSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungStockholms Läns LandstingNorges ForskningsrådUniversitair Medisch Centrum GroningenLundbeckfondenUniversitetet i OsloMinisterio de Ciencia e InnovaciónFondation de FranceUniversity of GalwayFundação de Amparo à Pesquisa do Estado do Rio Grande do SulHelse VestKarolinska InstitutetConselho Nacional de Desenvolvimento Científico e TecnológicoGedeon RichterGGZ DrentheNational Institute on AgingUniversität GreifswaldGGZ inGeestAccareBundesministerium für Bildung und ForschungVrije Universiteit AmsterdamUniversiteit UtrechtZonMwNational Natural Science Foundation of ChinaUniversiteit MaastrichtNational University of IrelandServierMaastricht Universitair Medisch CentrumUniversiteit LeidenH. Lundbeck A/SInstitut National de la Santé et de la Recherche MédicaleNederlandse Organisatie voor Wetenschappelijk OnderzoekDeutsche ForschungsgemeinschaftErasmus Medisch CentrumSouth African Medical Research CouncilFundação de Amparo à Pesquisa do Estado de São PauloAstraZenecaCanadian Institutes of Health ResearchKnut och Alice Wallenbergs StiftelseEuropean CommissionHelse Sør-Øst RHFMax-Planck-GesellschaftKing's College LondonAlzheimer's SocietyBioClinicaFresenius Medical Care North AmericaRivierduinenPfizerEU Joint Programme – Neurodegenerative Disease ResearchNational Alliance for Research on Schizophrenia and DepressionFoundation for the National Institutes of HealthHealth Research BoardFundación Alicia KoplowitzMrs Gladys Row Fogo Charitable TrustMinistry of Cultural AffairsFundación Mutua MadrileñaChildren's Hospital FoundationUniversiteit AntwerpenNorthern California Institute for Research and EducationNational Science FoundationGGZ FrieslandBiogenWellcome TrustAgence Nationale de la RechercheSiemens HealthineersFondation pour la Recherche MédicaleSouth London and Maudsley NHS Foundation TrustHersenstichtingCentro de Investigación Biomédica en Red de Salud MentalRadboud UniversiteitEli Lilly and CompanyLeids Universitair Medisch CentrumEisaiNational Institute on Drug AbuseAge UKEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentUniversity of Southern CaliforniaCommonwealth Scientific and Industrial Research OrganisationNational Institute for Health and Care ResearchCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorRijksuniversiteit GroningenBristol-Myers SquibbNovartis Pharmaceuticals CorporationSunovionScience Foundation IrelandU.S. Department of Health and Human ServicesUniversitetet i BergenUniversity of EdinburghAlzheimer's Disease Neuroimaging InitiativeMeso Scale DiagnosticsIXICOScottish Funding CouncilNational Healthcare GroupFédération pour la Recherche sur le CerveauAlzheimer's Association
KeywordsNeuroscienceBiologyPsychologyGenetic variantsEvolutionary biologyGeneticsGeneGenotype
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.915
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.031
GPT teacher head0.337
Teacher spread0.306 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itQuick stats
Citations252
Published2022
Admission routes2
Has abstractno