Editorial: Dictyostelium: A Tractable Cell and Developmental Model in Biomedical Research
Bibliographic record
Abstract
For almost a century, the social amoeba Dictyostelium discoideum has been used as an inexpensive and high-throughput model system for studying a variety of fundamental cellular and developmental processes including cell movement, chemotaxis, differentiation, and autophagy (Mller-Taubenberger et al., 2013; The life cycle of Dictyostelium is comprised of a unicellular growth phase and a 24-h multicellular developmental phase with distinct stages (Figure Dictyostelium development shares many common features with metazoan development but occurs in a much shorter time frame, which allows for the rapid detection of developmental phenotypes. The fully sequenced, low redundancy genome of Dictyostelium provides a less complex system to work with, whilst still maintaining many genes and related signalling pathways found in more complex eukaryotes The Dictyostelium genome is haploid, which allows researchers to introduce one or multiple gene disruptions with relative ease, and gene function can be studied in a true multicellular organism with measurable phenotypic outcomes
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".