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Record W4224980576 · doi:10.1016/j.msard.2022.103829

The metabolic potential of the paediatric-onset multiple sclerosis gut microbiome

2022· article· en· W4224980576 on OpenAlexafffund
Ali Mirza, Feng Zhu, Natalie Knox, Jessica D. Forbes, Christine Bonner, Gary Van Domselaar, Çharles N. Bernstein, Morag Graham, Ruth Ann Marrie, Janace Hart, E. Ann Yeh, Douglas L. Arnold, Amit Bar‐Or, Julia O’Mahony, Yinshan Zhao, William Hsiao, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett

Bibliographic record

VenueMultiple Sclerosis and Related Disorders · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGut microbiota and health
Canadian institutionsMcGill UniversityUniversity of TorontoSickKids FoundationUniversity of SaskatchewanSimon Fraser UniversityUniversity of ManitobaSaskatchewan Disease Control LaboratoryPublic Health Agency of CanadaHospital for Sick ChildrenUniversity of British Columbia
FundersJanssen CanadaCanadian Institutes of Health ResearchInstitute for Translational NeuroscienceNational Institutes of HealthCrohn's and Colitis CanadaMultiple Sclerosis Society of CanadaUniversity of ManitobaEmerald PublishingMultiple Sclerosis Scientific Research FoundationTakeda CanadaImmune Tolerance NetworkPublic Health Agency of CanadaBiogenPatient-Centered Outcomes Research InstituteAmerican Academy of NeurologyU.S. Department of DefenseGenome CanadaNovartisErasmus Medisch CentrumNational Multiple Sclerosis SocietyPfizer CanadaAlexion PharmaceuticalsRocheUniversity of British Columbia
KeywordsMultiple sclerosisInterquartile rangeMedicineMicrobiomeInternal medicineFecesPhysiologyImmunologyGastroenterologyBiologyBioinformaticsMicrobiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.197
Teacher spread0.186 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations13
Published2022
Admission routes2
Has abstractno

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