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Record W4225098762 · doi:10.53350/pjmhs2216410

Antiviral Activity of Extract of Neem (Azadirachta Indica) leaves: An in vivo study

2022· article· en· W4225098762 on OpenAlexaff
Rukhshan Khurshid, Sadia Majeed, Sumera Saghir, Maheen Saad, Huma Ashraf, Iram Fayyaz

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldMedicine
TopicHepatitis C virus research
Canadian institutionsContinental (Canada)
Fundersnot available
KeywordsAzadirachtaTraditional medicineHepatitis C virusBiologyMedicineVirusVirology

Abstract

fetched live from OpenAlex

Background: HCV in mainly replicate in liver cell and cause liver damage. The replication of HCV may be inhibited by leaves extract of neem (Azadirachta Indica). Aim: To find the antiviral activity of extract of neem (Azadirachta Indica) leaves. Methods: Thirty five hepatitis C positive and disappointment of conservative treatment were studied. Effect of neem (Azadirachta indica) leaves was seen in serum of patient. Extract of Azadirachta indica leaves was prepared and given orally to patients. The seropositivity of hepatitis C was estimated prior and after the leave extract of neem by HCV- RNA quantitative analysis by Polymerase chain reaction. Level of ALT, AST and total protein were estimated by standard kit methods. Results: A high HCV seropositivity was observed in patients before taking neem extract. We observed that after using the leave extract of Azadirachta indica or neem, the HCV seropositivity was significantly decreased. Levels of enzymes ALT and AST were also significantly decreased after taking neem extract. However, the level of serum protein was not changed. Conclusion: Extracted leaves of Azadirachta indica may serve as valuable regimen against hepatitis C virus as it has an ability to inhibit the protease responsible for replication of virus. Keywords: HCV seropositivity, Azadirachta indica leaves, transaminases

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.064
GPT teacher head0.387
Teacher spread0.323 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2022
Admission routes1
Has abstractyes

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