Risk Factors of Amyotrophic Lateral Sclerosis (ALS): An Updated Systematic Review
Bibliographic record
Abstract
Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting the voluntary motor nervous system. While the origin of ALS remains unclear, existing literature suggests multifactorial pathogenesis. Most cases appear sporadically, implicating the existence of environmental factors, while others suggest an underlying genetic mechanism. This study aims to summarize risk factors associated with the onset and progression of ALS. Methods: Three reviewers searched Medline database for English-language articles published between January 1, 2017 and November 6, 2021. Keywords included, but were not limited to, ALS, motor neuron disease, biomarkers, expos*, risk factors, and others. Included studies directly examined the effect of risk factors on ALS patients. Results were summarized descriptively following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Results: Overall, 310 unique articles were identified, of which 66 articles spanning 18 countries met the inclusion criteria. Thirty-five articles discussed environmental factors and reported 3 personal characteristics, 13 lifestyle factors, and 22 clinical factors being associated with ALS. Nineteen different genes were also discovered to be associated with ALS, while 13 genes were found to have no association. Discussion: Among environmental factors, lower socioeconomic status occupations were found to have a higher occurrence of ALS. Traumatic brain injuries are another clinical risk factor commonly associated with ALS. There are inconsistent associations between alcohol intake and ALS, and the link between ALS and viruses needs to be further explored due to a potential causal relationship. Some of the genes identified in this review are definitive ALS genes, but others are novel or have little supporting evidence, necessitating further research. Conclusion: With over 90% of ALS cases appearing sporadically, a great amount of research has gone into identifying the risk factors of the fatal illness. This study provides an updated systematic review that encompasses findings from 66 of the most current articles surrounding environmental and genetic risk factors of ALS. This paper provides researchers with a comprehensive summary of these risk factors to provide a springboard for future studies.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.016 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.005 |
| Science and technology studies | 0.001 | 0.004 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.005 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".