Editorial: Regulatory Mechanisms of Ca2+ Activated Ion Channels and Their Impact on Physiological/Pathophysiological Function
Bibliographic record
Abstract
The main goal of our Research Topic was to identify novel ionic, cellular and tissue level mechanisms that can regulate Ca 2+ -activated K + channel expression and function.An important secondary goal was to summarize current knowledge concerning the consequences of changes in channel activity for initiation and progression of human diseases, and related targets for drug discovery.We also recognized that to achieve these goals it would be necessary to present current knowledge of Ca 2+ -activated ion channel expression and function in intracellular organelles.We were therefore very pleased with the engagement of the international community in our Research Topic.This resulted in the submission, peer review, and acceptance of 11 very informative reviews or original research articles.The predominant focus that emerged was on the large conductance Ca 2+ -activated K + (BK) channels.Individual contributions focused on the ways in which BK channels form and then function as essential macromolecular signaling complexes, brought about (in part) by their alpha subunits being significant targets for pre-and posttranslational modifications (Sancho and Kyle).This functional theme is taken up and extended in the review by Shah et al., as they provide a succinct summary of what is now known about key aspects of spatially localized or nanodomain signaling complexes that have BK channels as their central element.These complexes can act as an electrophysiological negative feedback regulator for cellular membrane potential and/or agonistinduced changes in intracellular Ca 2+ .An interesting extension of this recent knowledge concerning spatially localized channel expression and related signaling is provided by the clear and concise review by González-Sanabria et al.These authors synthesize and present current knowledge concerning key aspects of the functions of BK channels that are localized to the inner mitochondrial membrane, as well as the outer membrane of the nuclear envelope.When combined, these contributions provide an up-to-date and readable platform of knowledge for beginning to consider the role of BK channels in specific chronic disease pathophysiology; as well as in regulation of cellular homeostasis paradigms (detection and regulation of transient and maintained hypoxia) that need to be recognized and understood as an essential first step for clinical management.For example, the review by Lu and Lee provides a timely summary of the ways in which down regulation of BK channel expression can contribute to vascular dysfunction in the setting of a debilitating chronic disease, diabetes mellitus.The review contributed by Ochoa et al., builds on the fundamental
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.009 |
| Meta-epidemiology (narrow) | 0.004 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.004 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.009 | 0.013 |
| Insufficient payload (model declined to judge) | 0.012 | 0.011 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".