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Record W4229370922 · doi:10.3390/solids3020019

Deposition of Organic-Inorganic Nanocomposite Coatings for Biomedical Applications

2022· article· en· W4229370922 on OpenAlex
Zhengzheng Wang, Igor Zhitomirsky

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueSolids · 2022
Typearticle
Languageen
FieldEngineering
TopicBone Tissue Engineering Materials
Canadian institutionsMcMaster University
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsMaterials scienceCoatingNanocompositeFabricationBiocompatibilityDissolutionDrug deliveryChemical engineeringComposite numberNanotechnologyComposite materialMetallurgy

Abstract

fetched live from OpenAlex

Polymethylmethacrylate (PMMA) is a material of choice for many biomedical coating applications. However, such applications are limited due to the toxicity of the traditional solvents used for the solution processing of PMMA coatings and composites. This problem is addressed using an isopropanol-water co-solvent, which allows for the dissolution of high molecular mass PMMA and the fabrication of coatings by a dip-coating method from concentrated PMMA solutions. The use of the co-solvent offers a versatile strategy for PMMA solubilization and coating deposition, despite the insolubility of PMMA in water and isopropanol. Composite coatings are obtained, containing hydroxyapatite, silver oxide, zinc oxide, micron size silica and nanosilica. Such coatings are promising for the manufacturing of implants with enhanced biocompatibility, bioactivity and antimicrobial properties and the fabrication of biosensors. Ibuprofen, tetracycline and amoxicillin are used as model drugs for the fabrication of PMMA-drug composite coatings for drug delivery. The microstructure and composition of the coatings are analyzed. The versatile dip-coating method of this investigation provides a platform for various biomedical applications.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.577
Threshold uncertainty score0.420

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.212
Teacher spread0.207 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it