The effects of intravenous pamidronate on the bone tissue of children and adolescents with osteogenesis imperfecta
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Bibliographic record
Abstract
Cyclical pamidronate infusions increase bone mass in children suffering from osteogenesis imperfecta.The histological basis for these effects remains unknown.Therefore, we compared parameters of iliac bone histomorphometry from 45 patients before and after 2.4 0.6 years of pamidronate treatment (age at the time of the first biopsy, 1.4-17.5 years; 23 girls).Although biopsy size did not change significantly (P = 0.30), cortical width increased by 88%.Cancellous bone volume increased by 46%.This was due to a higher trabecular number, whereas trabecular thickness remained stable.Bone surface-based indicators of cancellous bone remodeling decreased by 26-75%.There was no evidence for a mineralization defect in any of the patients.These results suggest that, in the growing skeleton, pamidronate has a twofold effect.In remodeling, bone resorption and formation are coupled and consequently both processes are inhibited.However, osteoclasts and osteoblasts are active on different surfaces (and are thus uncoupled) during modeling of cortical bone.Therefore resorption is selectively targeted, and continuing bone formation can increase cortical width.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it