Epstein-Barr Virus-Induced Polymorphic Nodal Lymphoproliferative Disorder Presenting as Recurrent Fever and Scrotal Swelling: A Case Report and Review of Literature
Bibliographic record
Abstract
Epstein-Barr virus (EBV) has been associated with the development of lymphoproliferative disorders (LPDs). Adults rarely develop systemic EBV-positive LPDs. We report a case of EBV-associated LPD presenting as recurrent scrotal swelling and fever for over nearly 30 years in an immunocompetent adult. A 64-year-old Caucasian male presented with generalized weakness, myalgia and fever associated with scrotal swelling and bilateral groin pain. He reported that these symptoms have recurred yearly for the past 30 years, lasting 1 - 2 days each. Systemic examination was normal except genital exam positive for scrotal swelling without tenderness and bilateral tender inguinal lymphadenopathy. Computed tomography (CT) scan of chest, abdomen and pelvis showed bilateral lymphadenopathy along external iliac chains and groins. Histopathological examination showed EBV-associated LPD and patient was started on rituximab. EBV is known to persist as a lifelong low-level infection in memory B cells of normal healthy carriers. Our patient’s disease course over three decades is likely secondary to this property, in the setting of an intact immune system. J Med Cases. 2016;7(8):354-357 doi: https://doi.org/10.14740/jmc2579w
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.004 | 0.004 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".