Nephrectomy in patients with Caroli’s and ADPKD may be associatedwith increased morbidity
Bibliographic record
Abstract
Autosomal dominant polycystic kidney disease (ADPKD), characterizedby multiple bilateral renal cysts, is the most commoninherited disorder of the kidney and an important cause of endstagerenal disease (ESRD). Caroli’s disease is a much less frequentcondition with ectasia of the intrahepatic biliary system. A clearassociation between autosomal recessive and Caroli’s disease hasbeen described, but only 4 cases of ADPKD and Caroli’s diseasehave been reported with 2 postoperative mortalities. The aim of thiscase is to increase the awareness of intra-operative and postoperativecomplications. A 66 year-old male was diagnosed with ADPKDand Caroli’s disease with hepatosplenomegaly and 4 episodes ofascending cholangitis. After 3 years of hemodialysis for ESRD, hereceived a cadaveric renal allograft. Subsequently, he developedparoxysmal atrial fibrillation. Upon anticoagulation, he developedmultiple episodes of gross hematuria from the left native kidney.After the anticoagulation therapy was discontinued, he underwentbilateral nephrectomies of his native kidneys. Intra-operatively, asplenic laceration could not be managed conservatively. Therefore,splenectomy was performed. In addition, he developed ascendingcholangitis post-operatively that was treated with antibiotics. Hewas discharged on postoperative day 18. Genetic testing revealedthat the patient is heterozygote for a large deletion in PKD1 gene,which encompasses all tested exons (exons 1-44).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".