Fifth International Workshop on the CCN Family of Genes: Abstracts and Posters October 18–22, 2008
Bibliographic record
Abstract
Matricellular proteins are present in the extracellular space, but do not perform structural functions.Rather, they modulate cell-matrix interactions and cell function by interacting with a wide variety of cell-surface receptors, cytokines and growth factors.The term 'dynamic reciprocity' has been applied to this process.Thrombospondins (TSPs) 1 and 2 resemble each other structurally and have similar properties when used as purified proteins in assays in vitro.However, physiologically they perform different functions, as judged by the phenotypes of TSP1 and 2-null mice, and by the fact that they do not compensate for each other in vivo.The latter finding can be explained by the very different promoter sequences in the thbs1 and thbs2 genes, which dictate different temporal and spatial expression of the two proteins in animals.This presentation will focus on the phenotype of the TSP2-null mouse, as elucidated by studies conducted in my laboratory during the past 10 years.In particular, I will emphasize the importance of a homeostatic function for both TSP1 and TSP2 in the inhibition of angiogenesis.This function, in contrast to the ligation of the CD36 receptor, which reduces vascularity by causing apoptosis of endothelial cells (EC), inhibits EC proliferation by a pathway that is initiated by interaction of TSPs with the very low density lipoprotein (VLDL) receptor.In effect, one can thus 'slow a car down by braking rather than by driving it over a cliff'
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".