The Abnormal Measures of Iron Homeostasis in Pediatric Obesity Are Associated with the Inflammation of Obesity
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Bibliographic record
Abstract
<p/> <p><it>Objectives</it>. To determine if the low iron state described in obese children is associated with the chronic inflammatory state seen in obesity. <it>Study Design</it>. Obese children age from 2 to 19 years seen at a weight management clinic were studied prospectively. Data were collected on age, gender, BMI, BMI <inline-formula><graphic file="1687-9856-2009-713269-i1.gif"/></inline-formula>-score, serum iron, ferritin, transferrin saturation, free erythrocyte protoporphyrin, high sensitivity creactive protein (hs-crp), and hemoglobin concentration. <it>Results</it>. 107 subjects were studied. Hs-crp levels correlated positively with BMI <inline-formula><graphic file="1687-9856-2009-713269-i2.gif"/></inline-formula> and BMI <inline-formula><graphic file="1687-9856-2009-713269-i3.gif"/></inline-formula>-score <inline-formula><graphic file="1687-9856-2009-713269-i4.gif"/></inline-formula> and negatively with serum iron <inline-formula><graphic file="1687-9856-2009-713269-i5.gif"/></inline-formula>. 11.2% of subjects had low serum iron. Median serum iron was significantly lower for subjects with American Heart Association high risk hs-crp values (<inline-formula><graphic file="1687-9856-2009-713269-i6.gif"/></inline-formula>3 mg/L) compared to those with low risk hs-crp (<inline-formula><graphic file="1687-9856-2009-713269-i7.gif"/></inline-formula>1 mg/L), (65 mcg/dL versus 96 mcg/dL, <inline-formula><graphic file="1687-9856-2009-713269-i8.gif"/></inline-formula>). After adjusting for age, gender, and BMI <inline-formula><graphic file="1687-9856-2009-713269-i9.gif"/></inline-formula>-score, serum iron was still negatively associated with hs-crp <inline-formula><graphic file="1687-9856-2009-713269-i10.gif"/></inline-formula>. <it>Conclusions</it>. We conclude that the chronic inflammation of obesity results in the low iron state previously reported in obese children, similar to what is seen in other inflammatory diseases.</p>
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it