Bibliographic record
Abstract
Angiotensin II (ANG II) generates reactive oxygen species (ROS) via an NADPH-oxidase in vascular system and leukocytes. ROS increase the formation of isoprostanes, which in turn increase the synthesis and release of endothelin (ET). ROS, isoprostane and ET are vasoconstrictors. ROS degrade nitric oxide (NO) a vasodilator. Superoxide, a member of the ROS family reacts with NO to generate peroxynitrite a potent oxidant. Peroxynitrite stimulates PGH 2 synthase and hence increases the production of thromboxane A 2 , a vasoconstrictor. Peroxynitrite also inhibits prostacyclin synthase that would result in decreased synthesis of prostacyclin a vasodilator. ROS and peroxynitrite would produce endothelial cell dysfunction resulting in a decrease in production of vasodilators and hence unopposed action of circulating vasoconstrictors. Ang II-induced hypertension is attenuated by antioxidants and this effect is associated with a reduction in oxidative stress. The evidence to date suggests that Ang II releases ROS by stimulating NADPH-oxidase in the vascular system and leukocytes. ROS directly or through synthesis and release of isoprostanes and ET, in activation of NO and generation of peroxyinitrite produces vasoconstriction and hence induce hypertension.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".