Cytopathology
Bibliographic record
Abstract
by dysfunction of the allograft. Hypothesis: Activation of complement in cardiac allograft recipients without allograft dysfunction may indicate that a protective mechanism exists. Design: Endomyocardial biopsies from 8 patients with complement deposition were compared. Four patients survived these episodes of AMR and 4 did not. Immunofluorescence staining of the endomyocardial biopsies was performed with the following markers: CD35 (Complement receptor 1, CR1), CD46 (Membrane Cofactor Protein, MCP), CD55 (Decay Accelerating Factor, DAF) and CD59 (Protectin). These markers are complement regulatory proteins which play a role in controlling and silencing complement activation and tissue injury or in removing complement complexes. Results: Patients with good response to therapy and resolution of the AMR episode showed intense tissue expression of these complement regulatory proteins in the endothelium of the allograft. Patiens with poor outcome had low or absent tissue expression of complement regulatory proteins. Conclusions: Local expression of complement regulatory proteins on the endothelial cell surface plays a role in controlling the deleterious effects of complement activation during episodes of AMR . Identification of these regulatory proteins in tissue and understanding of the mechanisms that control their expression will be a useful tool to predict outcome
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".