A275 DONOR BODY MASS INDEX (BMI) DOES NOT IMPACT RECIPIENT BMI FOLLOWING FECAL MICROBIOTA TRANSPLANTATION FOR RECURRENT CLOSTRIDIUM DIFFICILE INFECTION
Bibliographic record
Abstract
Fecal microbiota transplantation (FMT), which restores gut dysbiosis, is an effective treatment option for recurrent Clostridium difficile infection (RCDI). Although there are guidelines for stool donor screening to minimize risk of disease transmitted by stool, there are no recommendations on donor BMI. Obesity, a condition associated with intestinal dysbiosis, can be transferred by FMT in the mouse model. Further, there is a case report of a woman who developed new-onset obesity after receiving stool from a healthy but overweight donor. However, it remains unknown whether stool donor BMI has any significant impact on recipient BMI after FMT in RCDI. The aim of this study was to determine the impact of stool donor BMI on recipient BMI in RCDI. Forty-six patients with RCDI were randomized to receiving FMT by colonoscopy or by capsules (1:1) from one of three different volunteer donors registered with the Edmonton FMT Program. The donors are healthy and between the ages of 32–45, with BMIs of 18.3 kg/m2, 24.9 kg/m2, and 30 kg/m2. Pre-FMT weight and height were measured at screening visit, and weight was measured 1 week, 4 weeks and 12 weeks post-FMT. Weight lost during RCDI was recorded to calculate baseline BMI. Statistical measures were used to determine trends in weight loss from RCDI, changes in BMI over time, and effects of donor and method of FMT delivery on recipient BMI. There were no significant differences between participant baseline characteristics. The mean reported weight loss from RCDI was 5.44 ± 4.34 kg in the capsules arm and 3.72 ± 4.73 kg in the colonoscopy arm (p = 0.89). Participant BMI was significantly lower at time of FMT delivery when compared to reported baseline BMI (p < 0.05). Compared to BMI at baseline, BMI at week 12 was not significantly different, irrespective of donor or treatment method (Fig. 1). Fourteen patients (30%) gained weight 12 weeks post-FMT compared to baseline, but the difference was not statistically significant; furthermore, this observation was not donor or FMT method dependent. Our study highlighted the trends in weight recovery in RCDI patients after receiving FMT. Most patients regained weight lost during RCDI by week 12, irrespective of donor BMI or method of FMT delivery. For those patients who gained weight after FMT, the difference was not significant, and was not dependent of stool donor or FMT treatment modality. Trends of weight loss from RCDI. University of Alberta Hospital Foundation
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".