Ultrasound-mediated gene delivery: Cardiovascular applications for chronic ischemia, heart failure and ischemia-reperfusion injury
Bibliographic record
Abstract
Ultrasound-mediated gene delivery (UMGD) is a non-invasive gene transfer technique, utilizing high power ultrasound and DNA-bearing microbubbles. Despite modest transfection efficiency, its high organ, tissue specificity and repeatability make it an attractive therapeutic option. UMGD has been used in a variety of in vivo applications, including cardiac and skeletal muscle, kidney, liver, cerebral and even lung, and have been studied using many gene vectors, including plasmid, viral and small interfering RNA. This presentation will focus specifically on cardiac applications using plasmid DNA, including 1) introduction of UMGD in the heart, including optimization of parameters and protocols, 2) UMGD for therapeutic angiogenesis in chronic ischemia, including multi pro-angiogenic gene therapy and combination gene- and progenitor cell-based therapies for chronic hindlimb ischemia, and 3) applications for anti-apoptotic therapy in heart failure and ischemia-reperfusion injury.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".