Peer Review #2 of "Weekend effect in upper gastrointestinal bleeding: a systematic review and meta-analysis (v0.1)"
Bibliographic record
Abstract
Aim.To perform a systematic review and meta-analysis of the weekend effect on the mortality of patients with upper gastrointestinal bleeding (UGIB).Methods.The review protocol has been registered in the PROSPERO International Prospective Register of Systematic Reviews (registration number: CRD42017073313) and was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.We conducted a search of the PUBMED, COCHRANE, EMBASE and CINAHL databases from inception to August 2017.All observational studies comparing mortality between UGIB patients with weekend versus weekday admissions were included.Articles that were published only in abstract form or not published in a peerreviewed journal were excluded.The quality of articles was assessed using the Newcastle-Ottawa Scale.We pooled results from the articles using random-effect models.Heterogeneity was evaluated by the chisquare-based Q-test and I 2 test.To address heterogeneity, we performed sensitivity and subgroup analyses.Potential publication bias was assessed via funnel plot. Results.Eighteen observational cohort studies involving 1,232,083 study patients were included.Weekend admission was associated with significantly higher 30-day or in-hospital mortality in all studies (OR = 1.12, 95% CI: 1.07 -1.17, P < 0.00001).Increased in-hospital mortality was also associated with weekend admission (OR = 1.12, 95% CI: 1.08 -1.17, P < 0.00001).No significant difference in in-hospital mortality was observed between patients admitted with variceal bleeding during the weekend or on weekdays (OR = 0.99, 95% CI: 0.91 -1.08, P = 0.82); however, weekend admission was associated with a 15% increase in in-hospital mortality for patients with non-variceal bleeding (OR = 1.15, 95% CI: 1.09 -1.21, P < 0.00001).The time to endoscopy for weekday admission was significantly less than that obtained for weekend admission (MD = -2.50,95% CI: -4.08 --0.92,P = 0.002). Conclusions.The weekend effect is associated with increased mortality of UGIB patients, particularly in non-variceal bleeding.The timing of endoscopic intervention might be a factor that influences mortality of UGIB patients.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.009 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.025 | 0.006 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".