A138 LONG-TERM OUTCOMES AFTER PRIMARY BOWEL RESECTION IN PEDIATRIC-ONSET CROHN’S DISEASE
Bibliographic record
Abstract
There is limited evidence on the long-term outcome of intestinal resection in pediatric-onset Crohn’s disease (POCD) with no established predictors of adverse outcomes. We aimed to investigate clinical outcomes and predictors for adverse outcome following intestinal resection in POCD. The medical records of patients with POCD who underwent at least one intestinal resection between 1990 and 2014 were reviewed retrospectively. Main outcome measures included time to first flare, hospitalization, second intestinal resection and to non-prophylactic biologic therapy. Overall, 121 patients were included. Median follow-up was 6 years (range 1–23.6). One hundred and seven (88%) patients experienced at least one post-surgical exacerbation, 52 (43%) were hospitalized and 17 (14%) underwent second intestinal resection. Of 91 patients who underwent surgery after the year 2000, 37 (41%) were treated with anti-tumor necrosis factor α (anti-TNFα) (not prophylactic) following intestinal resection. Time to hospitalization and to second intestinal resection were shorter among patients with extra-intestinal manifestations (EIMs) (HR 2.7, P=0.006 and HR=3.1, P= 0.03, respectively). Time to initiation of biologic treatment was shorter in patients with granulomas (HR 2.1, P=0.038), while being naïve to anti-TNFα treatment prior to surgery was a protective factor for biologic treatment following surgery (HR 0.3, P=0.005). Undergoing intestinal resection beyond the year 2000 was associated with shorter time to first flare (HR 1.9, P=0.019) and hospitalization (HR 2.6, P=0.028). Long term risk for flares, hospitalization or biologic treatment is significant in POCD following bowel resection. EIMs increase the risk for hospitalization and second intestinal resection None
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".