Induced Normothermia After Severe Traumatic Brain Injury: A Prospective Observational Pilot Safety and Feasibility Study
Bibliographic record
Abstract
Background: Early hyperthermia following traumatic brain injury (TBI) is associated with worsened neurologic outcomes; however, eliminating fever has not been adequately studied. We sought to explore the safety and feasibility of induced normothermia using advanced fever control (AFC) in severe TBI patients. Methods: Eight patients underwent AFC with a surface cooling device for 96 hours, and four patients underwent conventional fever control (CFC). Average daily fever burden (FB) was calculated as the time and extent (°C × hours) above 37 °C. Shivering was evaluated hourly by the bedside shivering assessment scale (BSAS, 0 - 3) and BSAS > 0 was treated using a stepwise protocol. Results: FB was lower for the AFC vs. CFC group: 4.0 vs. 7.0 (P = 0.2) for day 1, 4.3 vs. 7.7 (P = 0.1) for day 2, 3.6 vs. 5.3 (P = 0.5) for day 3, 4.2 vs. 4.8 (P = 0.7) for day 4 respectively. BSAS > 0 developed more often in the AFC group (130 times) than the CFC group (two times). Conclusion: Induced normothermia was associated with less FB and more interventions to treat shivering compared to CFC in severe TBI patients. A large prospective randomized outcome trial of AFC vs. CFC is warranted. J Neurol Res. 2014;4(5-6):127-132 doi: http://dx.doi.org/10.14740/jnr283w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".