Development of Spatial Function in Rats and Associated C-Fos Patterns in the Hippocampal CA1 and CA3 Regions
Bibliographic record
Abstract
The hippocampus shows connectivity-based changes during development.The current work investigated the contribution of performance and cognitive factors in the emergence of spatial function during development.Experiment one showed a sensitive developmental period exists between 16 days old (p16) and p24.Experiment two found impaired performance on spatial learning following NMDAr blockade.Experiment three explored one-day of water maze training at p16, p18, or p20 and spatial learning was established only at p20.Quantification of c-Fos positive cells in CA3 and CA1 revealed a main effect of age, CA3 also revealed a main effect of training.Lastly, rats were trained on the dry maze at: p16, p17, p18, p19, or p20.Groups p19 and p20 demonstrated spatial learning.Quantification of c-Fos positive cells in CA1 revealed a main effect of age.This suggests that spatial memory mechanisms emerge at p19/p20 independently from performance factors and are based on hippocampal function.I would like to express my gratitude to my supervisor Dr. Matthew Holahan for his guidance and expertise throughout my degree.I appreciate the opportunity I was given coming from an Arts degree and the belief Dr. Holahan had in me to succeed in this program.To Catherine Smith and Brianne Wartman, for mentorship and guidance in the lab.Your patience and assistance allowed me to learn techniques, become independent and able to mentor new students
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".