Bibliographic record
Abstract
Even though ether was prepared in 1540 and nitrous oxide in 1774, it was not until the 1840s that these agents were used to induce anaesthesia to enable painless surgery. Modern inhalation anaesthesia has evolved from the public demonstration of ether anaesthesia by William Morton at the Massachusetts General Hospital, Boston, United States, on 16 October 1846. In the United Kingdom, from 1847 John Snow applied scientific principles to develop safer anaesthetic practice. Newer and safer agents have replaced ether in most countries. Successful intravenous anaesthesia began with chloral hydrate in 1874; progress was hesitant until the wide acceptance of thiopental from 1934—in turn superseded by propofol from 1985. Regional anaesthesia has evolved from the first use of the local anaesthetic, cocaine, to enable awake eye surgery by Carl Koller in 1884. This progressed to nerve blocks, spinal and epidural anaesthesia with a high degree of sophistication, through provision of better and safer local anaesthetics: lidocaine and bupivacaine. The introduction of neuromuscular blocking agents into anaesthetic practice began with the use of curare by Griffith and Johnson in Montreal in 1942. Muscle relaxation became a component of ‘balanced anaesthesia’—necessitating advances in airway management, including tracheal intubation and safe mechanical ventilation of the lungs. The modern anaesthetic workstation for inhalation anaesthesia has evolved from the early anaesthetic machines over 100 years. Of all the advances in anaesthesia during the past 50 years, developments in monitoring techniques—particularly pulse oximetry and capnography—have probably made the greatest contribution to patient safety. Anaesthetists have embraced enhanced postoperative recovery.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".