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Record W4239641275 · doi:10.1093/nar/gkn778

Mouse Phenome Database

2008· article· en· W4239641275 on OpenAlexfundno aff
Stephen C. Grubb, Terry P. Maddatu, Carol J. Bult, Molly A. Bogue

Bibliographic record

VenueNucleic Acids Research · 2008
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBioinformatics and Genomic Networks
Canadian institutionsnot available
FundersNational Center for Research ResourcesNational Institute of General Medical SciencesNational Human Genome Research InstituteNational Institute of Mental HealthNational Institute on AgingPfizerNatural Sciences and Engineering Research Council of CanadaNational Science FoundationTakeda OncologyNational Institutes of HealthNational Institute on Deafness and Other Communication DisordersCentre National de la Recherche ScientifiqueHebrew University of JerusalemAmerican Liver FoundationWellcome TrustNational Heart, Lung, and Blood InstituteNational Alopecia Areata FoundationJapan Heart FoundationNational Health and Medical Research CouncilAstraZenecaAmerican Health Assistance FoundationBristol-Myers SquibbGlaxoSmithKlineEllison Medical FoundationAmerican Heart AssociationDeutsche ForschungsgemeinschaftAndrew W. Mellon FoundationU.S. Department of Veterans AffairsU.S. Department of DefenseMedical Research CouncilMedical Research Council CanadaMarch of Dimes Foundation
KeywordsPhenomeBiologyIn silicoPhenotypeDatabaseTraitComputational biologyBioinformaticsGeneticsComputer scienceGene

Abstract

fetched live from OpenAlex

The Mouse Phenome Database (MPD; http://www.jax.org/phenome) is an open source, web-based repository of phenotypic and genotypic data on commonly used and genetically diverse inbred strains of mice and their derivatives. MPD is also a facility for query, analysis and in silico hypothesis testing. Currently MPD contains about 1400 phenotypic measurements contributed by research teams worldwide, including phenotypes relevant to human health such as cancer susceptibility, aging, obesity, susceptibility to infectious diseases, atherosclerosis, blood disorders and neurosensory disorders. Electronic access to centralized strain data enables investigators to select optimal strains for many systems-based research applications, including physiological studies, drug and toxicology testing, modeling disease processes and complex trait analysis. The ability to select strains for specific research applications by accessing existing phenotype data can bypass the need to (re)characterize strains, precluding major investments of time and resources. This functionality, in turn, accelerates research and leverages existing community resources. Since our last NAR reporting in 2007, MPD has added more community-contributed data covering more phenotypic domains and implemented several new tools and features, including a new interactive Tool Demo available through the MPD homepage (quick link: http://phenome.jax.org/phenome/trytools).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Software · Consensus signal: none
Teacher disagreement score0.050
Threshold uncertainty score0.169

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0060.005
Science and technology studies0.0010.000
Scholarly communication0.0020.002
Open science0.0030.002
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0500.034

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.049
GPT teacher head0.316
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreSoftware

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations87
Published2008
Admission routes1
Has abstractyes

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