H5N1禽流感病毒血凝素基因密码子的变异
Bibliographic record
Abstract
应用固定效应似然模型研究了作用于H5N1禽流感病毒血凝素基因的选择压力. 研究发现, 除2000年以外, 1997~2007年, H5N1病毒的血凝素基因都受到正选择压力的作用. 东南亚、中国香港和中国大陆的血凝素序列氨基酸多态性最复杂, 并且具有相似的非同义突变模式. 大部分地区的H5N1病毒血凝素基因的一些位点受到正选择压力的影响, 并且其中一些位点在不同地区的病毒中具有不同的氨基酸模式. 另外, 正选择压力对分离自欧洲、非洲和俄罗斯以及不同宿主类型的H5N1病毒产生了不同的影响. 一个位点只在取自人类的病毒中被发现受到正选择压力的影响. 尽管一些受到正选择压力的位点的功能尚不清楚, 但是本文的分析提供了H5N1禽流感病毒适应不同时间、地点和寄主的遗传证据.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.004 | 0.004 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.008 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".