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Record W4241317481 · doi:10.5489/cuaj.758

Treatment of angiomyolipoma at a tertiary care centre: the decision between surgery and angioembolization

2013· article· en· W4241317481 on OpenAlexaffvenueabout
Stephen Faddegon

Bibliographic record

VenueCanadian Urological Association Journal · 2013
Typearticle
Languageen
FieldMedicine
TopicTuberous Sclerosis Complex Research
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsMedicineNephrectomyAngiomyolipomaTertiary careSurgeryRadiologyKidneyInternal medicine

Abstract

fetched live from OpenAlex

Background: Angiomyolipoma (AML) is a benign renal neoplasm.First-line therapy includes renal preserving surgery or angioembolization(RAE), both with good outcomes in isolated studies.However, there are no comparative randomized trials and no clinicalguidelines to help clinicians decide between these treatmentmodalities. Our study examines the patterns of AML treatment ata tertiary care centre to evaluate how local urologists have beentreating this disease.Methods: This is a retrospective study of all AMLs treated at theVancouver General Hospital (Vancouver, BC, Canada) over thepast 10 years with either RAE or surgical excision. Searches wereperformed of the radiology and pathology dictation systems, usingthe following keywords: AML, angiomyolipoma, angioembolization,embolization, surgery, partial nephrectomy and nephrectomy.Results: At our institution, more AMLs were treated by surgerythan angioembolization (42 vs. 17 cases). Angioembolization wasmore often chosen for cases of multifocal AML (35% vs. 7%) andacute hemorrhage (50% vs. 14%). In the angioembolization cases,particles were the embolic agent of choice (used 40% of the time).Conclusions: Angioembolization allows rapid patient stabilizationin cases of acute hemorrhage, and provides good renal preservationin cases of multifocal AML. It may also be preferred in largemasses when partial nephrectomy is not feasible. Surgery should beperformed in cases of diagnostic uncertainty or complex vascularanatomy not amenable to RAE. Prospective randomized studies areneeded to compare RAE and surgery to better define their indicationsin sporadic AML.Contexte : Un angiomyolipome (AML) est une tumeur bénigne durein. Le traitement de première intention comprend une chirurgiede conservation rénale ou une angioembolisation rénale, quiont toutes deux donné de bons résultats dans des études isolées.Cependant, aucun essai comparatif randomisé n’a été mené et iln’existe pas de lignes directrices pour aider les cliniciens à choisirentre ces modalités thérapeutiques. Notre étude a examiné les tendancesdans le traitement de l’AML à un centre de soins tertiairespour évaluer comment les urologues y traitent cette maladie.Méthodologie : Il s’agit d’une étude rétrospective de tous les AMLtraités au Vancouver General Hospital (Vancouver, C.-B., Canada)au cours des 10 dernières années, soit par chirurgie de conservationrénale ou par angioembolisation. Des recherches ont été effectuéesdans les systèmes de dictée vocale de radiologie et de pathologieen utilisant les mots-clés anglais suivants : AML, angiomyolipoma,angioembolization, embolization, surgery, partial nephrectomy etnephrectomy.Résultats : Dans notre établissement, plus de cas d’AML ont ététraités par chirurgie que par angioembolisation (42 cas contre 17).L’angioembolisation a été plus souvent choisie dans les cas d’AMLmultifocal (35 % contre 7 %) et d’hémorragie aiguë (50 % contre14 %). Dans les cas traités par angioembolisation, les particulesont été l’agent embolique privilégié (utilisées dans 40 % des cas).Conclusions : L’angioembolisation permet de stabiliser rapidementl’état du patient en cas d’hémorragie aiguë, et offre une bonneconservation rénale en cas d’AML multifocale. Elle peut aussi êtrepréférable en présence de larges masses quand la néphrectomiepartielle n’est pas possible. La chirurgie doit être réalisée en casd’incertitude diagnostique ou d’anatomie vasculaire complexe nese prêtant pas à l’angioembolisation rénale. Des études prospectivesrandomisées sont nécessaires pour comparer l’angioembolisationrénale et la chirurgie afin de mieux définir leurs indications dansles formes sporadiques d’AML.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.036
Threshold uncertainty score0.573

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.249
Teacher spread0.225 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2013
Admission routes3
Has abstractyes

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