Bibliographic record
Abstract
Jim Watson is a towering figure in life sciences with major roles in elucidating the structure of DNA (1953) and bringing the human genome project to fruition (2000).Another major milestone for his biography is the distinction of being the first individual to have his genome sequence published [1].Watson's genome was analyzed to 7.4 redundancy allowing a detailed comparison against the publicly available reference human genome.This is a dubious ''first'' because other genomes have been sequenced, but amalgamated into the reference sequence.In 2000, I heard Craig Venter announce at the IUBMB conference in Birmingham, UK that his genome was one of several that contributed to the consensus.Watson chose to omit publication of his Apo E gene and the neighboring sequence associated with Alzheimer's disease.This is rather suggestive of an apo-E4 genotype and gives a pointer to the complications of making an entire genome available for analysis.It also gives a pointer to the inferences that can be made by withholding sequence information.The publication of Jim Watson's genome means that the age of universal sequencing is closer to reality, an age that will be opened by the awarding of the $10 million Archon-X prize for sequencing 100 human genomes in 10 days for $10,000 each (see later).It is good to see Watson receiving some positive attention to offset the vilification that followed his comments on the political abilities of Africans.Those comments were published in the Sunday Times, on October 14, 2007 and led to his suspension as chancellor of the Cold Spring Harbor Research Facility.This suspension gave rise to many commentaries on the propriety of Watson's comments and makes for an interesting analysis of the values of our times (see www.freerepublic.com/
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.017 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.004 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.006 | 0.004 |
| Open science | 0.002 | 0.003 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.832 | 0.736 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".