Bibliographic record
Abstract
Ranolazine is a piperazine derivative which produces its anti-ischemic effect by decreasing myocardial oxygen demand and enhancing myocardial perfusion without having any effect on heart rate or blood pressure. Many trials have proved its benefits in the management of chronic stable angina; however, some rare neurological side effects have been seen in elderly population. In this case report, we describe a case of a 75-year-old female with underlying coronary artery disease, chronic kidney disease and mild cognitive impairment who was admitted for a new onset auditory and visual hallucinations along with new onset tremors in both upper and lower extremity after she was started on ranolazine for management of her chronic stable angina. Her workup was negative for any source of infection and no metabolic derangements, drugs or stroke were found. Her symptoms resolved after the ranolazine was discontinued. We recommend starting ranolazine in elderly population only when other anti-ischemic therapies have been exhausted and starting with the lowest therapeutic dose possible. Ranolazine should be discontinued immediately if any signs of neurological adverse effect appear. We also recommend monitoring renal functions in these patients and withholding ranolazine if any signs of worsening renal functions appear. J Med Cases. 2017;8(3):90-92 doi: https://doi.org/10.14740/jmc2774w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".