Characterizing Thyroid Hormone Mediated Action on Gene Expression in Mice: Mechanistic Insight into Thyroid Hormone Response Elements, Thyroid Hormone Receptor-binding Sites, and MicroRNAs
Bibliographic record
Abstract
Genes identified as being directly regulated by THs.39 2.2Microarray and RT-qPCR results for known TH-regulated genes.41 2.3Microarray and RT-qPCR results for the male hypo+ and male hypo++ treatment groups.42 2.4TREs identified using bioinformatics searches of promoter regions of genes characterized as being directly regulated by THs.44 3.1Differentially expressed miRNAs in hypothyroid mouse liver.71 3.2Serum T4 levels of male pups in the various animal models.73 3.3Targets of miRs-1, 206, 133a and 133b that were significantly altered in hypothyroid mouse liver.79 4.1Genes associated with TR-binding site peaks found in all liver samples.98 4.2Putative TREs identified within top TR-binding sites peaks.104 4.3Fold changes determined by RT-qPCR for gene expression in the livers of juvenile.107 5.1Half-site organization for TRE constructs.129 SP2.1Altered genes in male pups, with a FDR-adjusted p < 0.05 in at least one of the treatment conditions.171 SP2.2 Altered genes in female pups, with a FDR-adjusted p < 0.05 in at least one of the treatment conditions.177 SP2.3The five most affected pathways, using the list of all significant along with the names of the genes that were affected by TH treatment within the pathway.186 SP4.1Genes associated with TR-binding site peaks found in at least two samples. 3.4Identification of the target genes of miR-206 regulated by TH. 81 4.1 Relative enrichment of TR binding sites identified by ChIP-chip using ChIP-PCR and gel quantification.101 4.2 Ddx54 expression in response to T3 in AML12 cells measured by RT-qPCR.109 4.3 Transcriptional activity determined by luciferase reporter assay for DR4.112 4.4 Alignment of the mouse and rat Thrsp promoter regions.Mm9 corresponds to mouse genome build 9 and Rn5 corresponds to rat genome build 5. 115 5.1 Transcriptional activity determined by luciferase reporter assay for DR4, IR0 and ER6.132 xi 5.2 Antagonistic effects of 1-850 determined by luciferase reporter assay for DR4.134 6.1 Summary of molecular mechanisms controlling TH-induced changes in mRNA levels revealed in this thesis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".