Peer Review #3 of "Segmental analysis by speckle-tracking echocardiography of the left ventricle response to isoproterenol in male and female mice (v0.1)"
Bibliographic record
Abstract
We studied by conventional and speckle-tracking echocardiography, the response of the left ventricle (LV) to a three-week continuous infusion of Isoproterenol (Iso), a non-specific beta-adrenergic receptor agonist in male and female C57Bl6/J mice.Before and after Iso (30 mg/kg/day), we characterized LV morphology and function as well as global and segmental strain.We observed that Iso reduced LV ejection in both male (-8.7%) and female (-14.7%)mice.Several diastolic function parameters were negatively regulated in males and females such as E/A, E/E', isovolumetric relaxation time.Global longitudinal (GLS) and circumferential (GCS) strains were reduced by Iso in both sexes, GLS by 31% and GCS by about 20%.For the segmental LV analysis, we measured strain, strain rate, reverse strain rate, peak speckle displacement and peak speckle velocity in the parasternal long axis.We observed that radial strain of the LV posterior segments were more severely modulated by Iso than those of the anterior wall in males.In females, on the other hand, both posterior and anterior wall segments were negatively impacted by Iso.Longitudinal strain showed similar results to the radial strain for both sexes.Strain rate, on the other hand, was only moderately changed by Iso.Reverse strain rate measurements (an index of diastolic function) showed that posterior LV segments were negatively regulated by Iso.We then studied the animals 5 and 17 weeks after Iso treatment.Compared to control mice, LV dilation was still present in males.Ejection fraction was decreased in mice of both sex compared to control animals.Diastolic function parameters, on the other hand, were back to normal.Taken together, our study indicates that segmental strain analysis can identify LV regions that are more negatively affected by a cardiotoxic agent such as Iso.In addition, cessation of Iso was not accompanied with a complete restoration of cardiac function after four months.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.016 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.111 | 0.066 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".