Abstracts of the Joint Annual Meeting of Immunology of the Austrian and German Societies (ÖGAI, DGfI), Vienna, September 3–6, 2008
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Bibliographic record
Abstract
Pre-eclampsia is a systemic disease of unknown aetiology. It is the leading cause of morbidity and mortality in pregnancy. Preeclampsia has been suggested to represent rejection of the fetus by the maternal immune system, as a consequence of imbalances within the T helper cell subsets. In this study we analysed intracellular expression of FoxP3, IFN, IL-10 and IL-17 within the CD4 subsets by flow cytometry. These subsets were compared between nonpregnant women, and women at the end of the third trimester in healthy and pre-eclamptic pregnancies, both in peripheral blood and decidual tissue. Circulating CD4+FoxP3+ Treg frequencies in healthy pregnancies were comparable to non-pregnant controls (6.63% +/-1.91 vs. 6.69% +/-1.29), but were markedly reduced in preeclampsia (4.29% +/-1.97). Functional differences in Treg cells were not observed between the different cohorts. The cytokine patterns within the CD4+ T cell subset showed a significantly higher proportion of Th17 cells in patients with pre-eclampsia, when compared to healthy pregnancies (1.03% +/-0.53 vs 0.41% +/-0.38). Consequently, the ratios of IL17+/IFN+ cells as well as IL17+/IL10+ cells were significantly higher in pre-eclamptic compared to healthy pregnancies. In addition, decidual CD4+FoxP3+ Tregs and Th17 cells were maintained at comparable levels in healthy pregnancies and in pregnancies with pre-eclampsia. We now provide evidence that the Treg/Th17 balance of circulating lymphocytes is skewed towards the Th17 cell lineage in preeclampsia. These results are suggestive that Treg/Th17 homeostasis might be essential for the semiallogeneic fetus to be tolerated within the maternal environment.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it