Pressor Responses to Central Sodium and Ouabain Are Attenuated in Transgenic Rats Deficient in Brain Angiotensinogen
Bibliographic record
Abstract
P195 Studies using AT 1 -blockers suggest that the brain renin-angiotensin system (RAS) contributes to sympatho-excitation and hypertension by high dietary salt or central sodium loading. To more specifically examine this role of the brain RAS, [TGR (AsrAOGEN)] transgenic rats were used. These rats express an antisense RNA against angiotensinogen mRNA specifically in the brain, and the brain angiotensinogen level is reduced by more than 90%. In freely moving TGR and SD controls, BP and HR responses to intracerebroventricular (icv) infusion (3.8 μl/min for 10 min) of artificial CSF (aCSF) and Na + -rich aCSF (containing 0.2, 0.3 and 0.45 M Na + ) as well as icv injection of ouabain (0.3 and 0.6 μg/2 μl) were assessed. The vasopressin antagonist [d(CH 2 ) 5 Tyr(Me)]AVP (30 μg/kg) was given iv before each icv infusion. Data are means±SEM (n=6, for each).* p<0.05, vs SD rats. Somewhat surprisingly, angiotensin I and II levels of not only hypothalamus but also plasma were lower in TGR vs. SD rats. The clearly attenuated sympatho-excitatory and pressor effects to ouabain and Na + -rich aCSF support the concept that the brain RAS plays an important role in the sympatho-excitatory effects of ouabain and CSF sodium.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".