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Record W4247575608 · doi:10.14785/lpsn-2015-0901

Immunodeficiency Canada Satellite Symposium at 2014 Canadian Society of Allergy and Clinical Immunology Annual Scientific MeetingOctober 23, 2014Delta Ottawa CentreOttawa, ON

2015· article· en· W4247575608 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.
venuePublished in a venue whose home country is Canada.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.

Bibliographic record

VenueLymphoSign Journal · 2015
Typearticle
Languageen
FieldImmunology and Microbiology
TopicImmunodeficiency and Autoimmune Disorders
Canadian institutionsMemorial University of NewfoundlandUniversity of British ColumbiaJaneway Children's Health and Rehabilitation CentreBritish Columbia Children's HospitalChild and Family Research Institute
FundersImmunodeficiency Canada
KeywordsClinical immunologySatelliteHuman immunodeficiency virus (HIV)MedicineImmunologyAllergyEngineering

Abstract

fetched live from OpenAlex

Chronic Granulomatous Disease (CGD) is a primary immunodeficiency caused by mutations that disable the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme complex. This dysfunction subsequently leads to decreased or absent production of reactive oxygen species required for phagocytic killing of certain pathogens. CGD can be inherited in an X-linked or autosomal recessive fashion. The different genetic forms of CGD vary in their residual NADPH oxidase function and can thus be differentiated based on this quantification. Importantly, residual reactive oxygen species production has been correlated with long-term prognosis for patients with CGD (Kuhns et al. 2010).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Science and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.175
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.223
Teacher spread0.213 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it