Serologic Screening of Celiac Disease in Patients With Type 1 Diabetes
Bibliographic record
Abstract
Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disorder associated with increased risk of additional autoimmune diseases (ADs) as celiac disease (CD). The aim of this study was to investigate the prevalence of CDs in a population of diabetic children along with the presence of any suggestive clinical signs and symptoms of CD and any effects of CD on the patients’ diabetic control and growth. Methods: Data from diabetic patients in South Jordan attending the diabetic clinic in the military hospital between 2014 and 2015 were collected. The frequency of CD was calculated. A t -test comparison between CD-seropositive and seronegative diabetic patients, the unadjusted and adjusted odds ratios (ORs) for age, gender, baseline glycated hemoglobin (HbA1c), cholesterol and glucose levels, associated diseases, and body mass index with their 95% confidence intervals (CIs) were evaluated. Results: One hundred thirty-eight patients with T1DM (median age 16.5 years; 74 females) were recruited. The results showed that CD was in (6.5%) of the patients. The body weight, body mass index, baseline HbA1c and cholesterol levels were significantly different between seropositive and seronegative patients (P < 0.05). Adjusted ORs for the presence eczema and family history of T1DM in seropositive CD were 32.66 (95% CI: 2.68 - 398.85, P = 0?.0006), and 5.79 (95% CI: 1.07 - 31.33, P= 0.041), respectively. While the adjusted odd ratio of having high HbA1c and high cholesterol levels in seropositive were 1.76 (95% CI: 1.13 - 2.74, P = 0.01) and 1.02 (95% CI: 1.006 - 1.031, P < 0.001) respectively. Conclusions: These findings suggest a need for a careful surveillance of CD in patients with T1DM. This may help in improving the diabetic control and growth control, and avoidance of complications. J Endocrinol Metab. 2018;8(2-3):37-42 doi: https://doi.org/10.14740/jem507w Correction in J Endocrinol Metab. 2020;10(1):32, doi: 10.14740/jem507wc1
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".