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Record W4248650010 · doi:10.1159/000162431

Cells Involved in the Immune Response

2008· article· en· W4248650010 on OpenAlexaff
R. Haasz, M. Richter

Bibliographic record

VenuePathologia et Microbiologia · 2008
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicRabbits: Nutrition, Reproduction, Health
Canadian institutionsMcGill University
Fundersnot available
KeywordsLymphatic systemImmune systemSpleenBiologyPopulationBone marrowAntigenImmunologyLymph nodeAntibodyLymphocyteCell biologyMedicine

Abstract

fetched live from OpenAlex

It has been shown that extirpation of the thymus, the spleen, and the SAPP organs (appendix, sacculus rotundus and Peyer’s patches) in the normal adult rabbit does not affect the capacity of the rabbit to mount a humoral immune response to either particulate (SRBC or HRBC) or soluble protein (HSA or BGG or OA) antigens. Since it has previously been shown that the bone marrow does not constitute the organ capable of providing the host with the antibody-forming cells (AFC), it is concluded that no single lymphoid organ in the immunologically mature rabbit at the time of immunization constitutes the source of virgin AFC or serves as a necessary site of maturation of the AFC. Furthermore, the spleen, thymus and SAPP organs do not appear to possess any hormonal function with respect to the maintenance of immunocompetent cells. It is assumed that no single lymph node or the unorganized lymphoid cell accumulations or infiltrations would possess this unique role. It is, therefore, postulated that either all the lymphoid organs in the mature, adult rabbit possess virgin AFC or that the AFC represents a transient stage of morphological development of a potentially immunocompetent population of lymphocytes. Evidence has been presented that these cells, ontogenetically, probably arise in the gut-associated (SAPP) lymphoid organs and disseminate and infiltrate the other lymphoid organs either prenatally or in the early postnatal period.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.905
Threshold uncertainty score0.318

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.244
Teacher spread0.210 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2008
Admission routes1
Has abstractyes

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