Human rGDF-11 Counteracts Age-Related Short-Term Memory Impairments in Middle-Aged Mice
Bibliographic record
Abstract
In humans, visuospatial memory begins to decline as early as the mid-30s, yet the mechanisms involved in this phenomenon are poorly understood. Recent research suggests that growth differentiation factor-11 (GDF-11) can have a beneficial impact on cognitive ability in old age. The mechanisms mediating this effect are unclear and there is currently no information regarding potential impact of GDF-11 on cognitive ability in the middle age years. The goal of this thesis was to explore the effects of GDF-11 treatment on the cognitive ability in middle-aged mice. Young mice and middle aged mice were treated with GDF-11 and the impact on short term memory was evaluated. The data showed significant improvement in the performance of visual memory tasks and increased neurogenesis in middle-aged mice. Taken together, these results suggest that GDF-11 is a promising candidate for combating the age-related cognitive decline associated with middle age.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".