Correction: Trauma Association of Canada abstracts
Bibliographic record
Abstract
Background: Hyperfibrinolysis (HF) is uncommon after trauma but carries a high mortality.In practice, thromboelastometry (i.e., ROTEM) is the only test capable of diagnosing HF during initial resuscitation.We used ROTEM to study whether patients with traumatic brain injury (TBI) have HF on hospital admission.Methods: Review of all adult trauma patients with ROTEM on admission to Trauma Centre, grouped as: isolated TBI (Abbreviated Injury Score [AIS] head ≥ 2 and non-AIS head ≤ 1); no TBI (AIS head ≤ 1) and concomitant TBI/non-TBI injuries.Hyperfibrinolysis was "lethal" if ROTEM clot lysis (CLI30) was abnormal or maximum lysis (ML) was 100%, or nonlethal if ML was 99% or lower.Coagulopathy was abnormal ROTEM, international normalized ratio of 1.5 or more, or partial thromboplastin time of 40 seconds or more.Statistics used were the Student t test and logistic regression.Results: A total of 974 patients (August 2011-December 2012) had admission ROTEM; 207 had isolated TBI; 447 had no TBI; 320 had both.Groups were similar except for significantly higher Injury Severity Score (26 admission ROTEM, 18 isolated TBI/13 non-TBI); more blood transfusion; more coagulopathy in concomitant TBI/non-TBI group.Lethal HF was diagnosed in 0 patients with isolated TBI; 0.44% non-TBI patients (mortality 100%) and 5.9% concomitant TBI/non-TBI injuries (mortality 63%) (p < 0.001).Nonlethal HF was diagnosed in 36%, 40% and 30% (mortality 12%, 2.2% and 5.3%, respectively, mostly of TBI).Injury Severity Score (OR 1.11, 95% CI 1.08-1.14)was associated with HF but not TBI.Conclusion: Lethal HF though infrequent, carries prohibitive mortality (up to 63%).No patient with isolated TBI had lethal HF on admission, while in others it was diagnosed in up to 5.9%.Nonlethal HF was similarly diagnosed in all groups.ISS (but not TBI) was closely associated to HF suggesting that the extent of tissue destruction and not injury to specific tissues (i.e., brain) is the mechanism underlying hyperfibrinolysis in trauma.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.037 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.006 | 0.007 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.006 | 0.003 |
| Open science | 0.003 | 0.002 |
| Research integrity | 0.005 | 0.007 |
| Insufficient payload (model declined to judge) | 0.244 | 0.095 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".