Long-term follow up of limited stage primary testicular lymphoma: Outcome and patterns of relapse after combined-modality treatment
Bibliographic record
Abstract
6588 Background: To assess the outcome and patterns of relapse in patients (pts) with limited stage primary testicular lymphoma treated with chemotherapy and irradiation. Methods: We retrospectively evaluated the outcome and patterns of relapse in pts treated at the BC Cancer Agency for limited stage (IAE or II AE) primary testicular lymphoma. Patients who were consecutively treated from 1980–1995 were selected to reflect a change in treatment policy to combined-modality therapy, consisting of brief CHOP type chemotherapy for 3 cycles followed by total scrotal irradiation. Prophylactic intrathecal chemotherapy was not given. Results: 39 pts were identified, with median age 72 years (42–84). Median follow-up is 70 months (2–161). All pts had diffuse large B cell lymphoma; 15(38%) pts had Ann Arbor stage IAE and 24(62%) pts had stage IIAE. 6 patients had elevated LDH at presentation, but none above 1.2 x upper limit of normal. 33(85%) pts had an ECOG performance status of 0 or 1. 27(69%) pts had an IPI score of 1, 8 pts of 2, 1 pt of 3 and 3 younger pts had a IPI score of 0. 5 pts were not treated, 4 were elderly and frail and 1 pt refused recommended treatment. 34 pts received combined-modality therapy. There were 13(38%) relapses, 10 occurring more than 2 yrs past diagnosis(range 2–10yrs). 5 pts relapsed with brain parenchymal lesions, 2 with distant cutaneous sites, 3 in retroperitoneal lymph nodes (RPLN), 1 with paraspinal mass, 1 with contralateral testis and RPLN and 1 with multiple nodal sites. 5-yr and 10-yr disease-specific survival were 75% and 55% respectively. The median disease-free survival and overall survival were 11.5 and 5.8 yrs respectively. Conclusions: Patients with limited stage primary testicular lymphoma who undergo combined-modality treatment are at risk for late relapses at extranodal sites, with particular predilection for skin and brain parenchyma but not leptomeninges. Future study designs will need to address this issue. No significant financial relationships to disclose.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".