Bibliographic record
Abstract
A 74-year-old white woman with lichen planus and hemoglobin 130g/L was started on 100 mg of dapsone daily.Within 2 weeks she developed progressive fatigue, shortness of breath on exertion, yellowing of her skin, and dark urine.By the time she was assessed and admitted to hospital approximately 4 weeks later, her hemoglobin was 75g/L with elevated LDH, reticulocyte count, and indirect bilirubin.She was otherwise healthy and was not on any other medications.There was no family history of anemia or G6PD deficiency.The antiglobulin test was negative, and a G6PD test was not ordered.The dapsone was discontinued and she received 3 units of red blood cell concentrates.One week later she was seen by hematology.The hemoglobin, reticulocyte count, and indirect bilirubin had returned to normal.The original peripheral blood smear was unavailable but the current smear showed "bite" cells (see arrows in figure).The direct antiglobulin test remained negative and Heinz bodies were not seen on supravital stains.The patient did not return for further assessment and G6PD testing.Dapsone is an antibacterial agent used for infections such as Mycobacterium tuberulosis.It has anti-inflammatory and immunomodulatory properties that may be useful in various skin diseases such as lichen planus.Dapsone metabolites can lead to oxidative stress, denatured hemoglobin, and methemoglobinuria.Occasionally, "bite" cells can be seen on peripheral smears.Patients receiving dapsone should be assessed for evidence of hemolysis.For additional images, visit the ASH IMAGE BANK, a reference and teaching tool that is continually updated with new atlas and case study images.For more information visit http://imagebank.hematology.org.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".