ACUTE MYELOID LEUKAEMIA, MIXED PHENOTYPE ACUTE LEUKAEMIA, THE MYELODYSPLASTIC SYNDROMES AND HISTIOCYTIC NEOPLASMS
Bibliographic record
Abstract
Acute myeloid leukaemia (AML) is a disease resulting from the neoplastic proliferation of a clone of myeloid cells, characterized by uncoupling of proliferation and maturation. Immunophenotyping is widely applied in the diagnosis and classification of AML. It is likewise necessary for the recognition of mixed phenotype acute leukaemia (MPAL). In hypoplastic myelodysplastic syndromes (MDS) there may be some circulating blast cells and an inadequate bone marrow aspirate, whereas there is no increase in blast cells in aplastic anaemia. Lymphoid aggregates are sometimes present in MDS, giving rise to a differential diagnosis with non-Hodgkin lymphoma, particularly T-cell lymphoma, with associated dysplastic features. Histiocytic sarcoma differs from myeloid sarcoma with monocytic differentiation in that the neoplastic cells have features of tissue histiocytes rather than of promonocytes and monocytes. Juvenile xanthogranuloma is usually a clinically benign, localized condition but when the disease is disseminated the bone marrow may be involved.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.020 | 0.008 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".