Abstract P324: Abdominal Visceral Adiposity and Liver Fat in Relation to Sex-Related Differences in Cardiometabolic Risk Profile: The INSPIRE ME IAA Study
Bibliographic record
Abstract
Objectives: Sex differences in the cardiovascular risk profile are well established. The objectives of the present analyses were 1) to characterize sex differences in visceral adiposity (VA) and estimated liver fat content assessed by computed tomography (CT) and in the cardiometabolic risk (CMR) profile in a large international multiethnic cohort; 2) to determine whether differences between men and women in CMR factors remain after controlling for VA and/or liver fat. Methods: In the International Study of Prediction of Intra-abdominal adiposity and its Relationship with cardioMEtabolic risk/Intra-Abdominal Adiposity (INSPIRE ME IAA), 297 primary care physicians, cardiologists, endocrinologists/diabetologists recruited 4504 patients from 29 countries. VA and liver attenuation (inversely correlated to liver fat) were assessed by CT. Cardiometabolic risk factors (triglyceride (TG), HDL-C, Apolipoprotein B (ApoB), HOMA, 2h-glucose (OGTT), adiponectin, C-Reactive Protein (CRP)) were assessed using standardized methods. The present cross-sectional analyses were performed in 1193 men and 1214 women free of type 2 diabetes. Results: Whereas mean BMI was similar in women and men (27.5±0.1 vs 27.5±0.1 kg/m2), men had higher waist circumference (98.1±0.4 vs 89.6±0.4 cm), higher VA (165±2 vs 131±2 cm2) and lower liver attenuation (54.9±0.3 vs 57.4±0.3 HU) (p<0.0001 for all) than women. Men displayed higher TG and HOMA but lower HDLc, CRP and adiponectin levels (p<0.001 for all) than women. In both sexes, VA and liver fat were significantly correlated positively with CMR variables: TG, HOMA and CRP and negatively with HDLc and adiponectin (p<0.05 simple regression analysis). In multiple regression analyses, VA and liver attenuation independently affected CMR variables. Sex differences in TG were eliminated after adjustment for VA or both variables simultaneously but HDLc remained higher in women even after such adjustment. HOMA was higher in women when adjusted for VA or for both variables and similar to men when adjusted for liver attenuation. Being not different between sexes before adjustment, 2h-glucose was higher in women when controlling for VA/liver fat. Adiponectin remained higher in women after all adjustments. Sex differences in CRP were magnified after adjustment for VA/liver fat and remained higher in women. Conclusion: In this large standardized international CT-imaging/cardiometabolic study, substantial sex differences in abdominal adiposity/liver fat and CMR factors were observed, with men presenting an overall more deteriorated CMR profile than women. Controlling for VA and liver fat was not sufficient to abolish sex differences in all inflammatory, insulin sensitivity or lipid factors.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".