HG-109CONTEMPORARY SURVIVAL ENDPOINTS: AN INTERNATIONAL DIFFUSE INTRINSIC PONTINE GLIOMA REGISTRY STUDY
Bibliographic record
Abstract
BACKGROUND: Rapidly evolving insight into the biology of diffuse intrinsic pontine glioma (DIPG) is translating into robust development of clinical trials. Determination of therapeutic benefit after time of progression remains difficult to assess. We sought to measure survival endpoints in a large, contemporary international DIPG population. METHODS: Patients registered in the International DIPG registry, fulfilled pre-defined DIPG diagnostic criteria, and diagnosed between January 1st, 2004 and January 1st, 2014 were eligible. PFS was defined as time from diagnosis to date of radiographic progression or death from any cause. Time to progression (TTP) was time of diagnosis to date of radiographic progression, death was censored. Overall survival (OS) was defined as time of diagnosis until death or censorship. Post-progression survival (PPS) was measured both as OS minus TTP and OS minus PFS. RESULTS: We identified 253 patients; 103 patients did not have a documented date of progression. Median OS was 10.7 months, percent OS at 1,2,5 year (40, 8, 0). Median PFS was 6.9 months. Median TTP was 5 months. Median PPS as OS-PFS was 2 months, percent PPS at 6 month, 9 month (23,12). Median PPS as OS-TTP was 4.8 months, percent PPS at 6 month, 9 month (38,19). CONCLUSIONS: Our study is the first to define survival endpoints in a large, contemporary DIPG population. Differences in PFS and TTP and thus PPS measurements are directly related to the large portion of patients without progression data. Future work requires a collaborative effort to optimally define progression and survival endpoints.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".