Assessment of the Aquatic Release and Relevance of Selected Endogenous Chemicals: Androgens, Thyroids and Their<i>in Vivo</i>Metabolites
Bibliographic record
Abstract
Endogenous chemicals released through anthropogenic excretions enter the environment on a continuous basis. Therefore, it is important to establish their rate of introduction into the environment. An approach was developed to establish such environmental loads for any given endogenous chemical that is likely to be released in anthropogenic excretions. The approach developed was used to quantify influent, effluent and surface water loads of 25 endogenous chemicals including androgens, thyroids and their in vivo metabolites, using the United States as an illustrative case. The predicted surface water concentrations matched up well with the limited monitoring data presently available. The environmental relevance of the surface water presence could only be assessed for 5 of the 25 endogenous chemicals due to limited availability of eco-toxicological data. Data available thus far suggest that testosterone, dihydrotestosterone, thyroxine, triiodothyronine are unlikely to pose a risk to the receiving aquatic ecosystem when considered individually. However, androstenedione is predicted to pose a potential risk to the receiving environment in situations where the surface water dilution of the effluents is expected to be low.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".