PD42-10 EFFECTS OF SILICONE HYDROCOATED DOUBLE LOOP URETERAL STENT (DJ) ON SYMPTOMS AND QUALITY OF LIFE IN PATIENTS UNDERGOING F-URS FOR KIDNEY STONE: FINAL RESULTS OF A PROSPECTIVE RANDOMIZED MULTICENTRE CLINICAL STUDY
Bibliographic record
Abstract
INTRODUCTION AND OBJECTIVES: Current AUA Best Practice Statement recommends antibiotic prophylaxis for cystoscopy with manipulation, including stent removal, although no level 1b trials explicitly address prophylaxis for stent removal.We sought to prospectively determine the efficacy of prophylactic antibiotics to prevent infectious complications after cystoscopic stent removal.METHODS: Following IRB approval, subjects undergoing removal of ureteral stent placed during stone surgery were recruited at UC San Diego and Genesis Healthcare from July 2016 to October 2018.Co-variates included age, BMI, comorbidities, surgery type, stone composition, UTI history, bladder urine culture (UCx) at stone surgery, bladder UCx and post-void residual at time of stent removal.Subjects were recruited at time of stent removal and randomized to treatment (single dose 500mg oral Ciprofloxacin) or control group (nothing).Subjects with indwelling stents longer than 3 weeks were excluded.Telephone contact with subject was performed 14 days after stent removal to assess for UTI symptoms, antibiotic prescriptions, or ED visits.Primary outcome was UTI within 2 weeks of stent removaldefined by irritative void symptoms, fever or abdominal pain associated with clean catch culture >100k colonies/mL.RESULTS: To date, 65 subjects have been enrolled with 46 meeting final inclusion criteria for analysis (26 treatment, 20 control).No differences were seen with clinical and demographic variables (all p>0.053).Positive Ucx rate prior to stone surgery (16.7% vs. 11.8%,p[0.819) and at time of stent removal (16.0% vs. 11.1%,p[0.648) was not significantly different in treatment vs. control groups, respectively.Primary outcome: No subjects in either cohort developed symptomatic culture-diagnosed UTI within two weeks of stent removal.Of those subjects with documented phone follow up (Treatment n[22, Control n[19), no subjects in either group reported fever, seeing a physician or an emergency department for urinary complaints, receiving additional antibiotics or being admitted for infection.CONCLUSIONS: Initial data suggests antibiotic prophylaxis for cystoscopic removal of ureteral stents does not reduce infectious complication rate.Completion of the trial will help determine if the necessity of antibiotics during routine cystoscopic stent removal warrants AUA Best Practice Statement re-evaluation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.003 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".