SCIENTIFIC ABSTRACTS – Skin Disease Education Foundation’s 42nd Annual Hawaii Dermatology Seminar
Bibliographic record
Abstract
BACKGROUND: Almost fi fty percent of patients with schizophrenia experience some type of dermatitis.The standard treatment for dermatitis is a topical corticosteroid.Despite their demonstrated effectiveness, topical corticosteroids are associated with various side effects that may limit their use.These include generalized adverse effects from systemic absorption, such as suppression of the hypothalamic-pituitary-adrenal axis.OBJECTIVES: While dose-related, oral corticosteroid-induced psychiatric symptoms, such as psychosis, are well documented, the literature is devoid of topical corticosteroids precipitating psychosis.We hope to provide additional perspective on this phenomenon.METHODS: We present a case of a patient with schizophrenia who developed morphea.She was liberally treated with the potent topical corticosteroid clobetasol, possibly resulting in a supraphysiologic exposure.Subsequently, our patient developed an exacerbation of active-phase symptoms of schizophrenia RESULTS: After clobetasol administration was reduced, these active phase symptoms dissipated.LIMITATIONS (If any): Small sample size, purported fi rst case.CONCLUSION: Given the complex associations between cortisol, the HPA axis, and the development of schizophrenia, it is highly plausible that exogenous glucocorticoids play some role in either an exacerbation of primary psychotic symptoms or an increased susceptibility to them.Our case serves to highlight and association between topical corticosteroids, a therapy commonly used by dermatologic providers, and a rare systemic sequelae to further guide management in complex patients with multiple comorbidities.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".