Bibliographic record
Abstract
The aim of this symposium was to consider the present-day knowledge of the cellular and humoral mediators of anaphylaxis and allergy, including the chemical mediators of acute inflammation.Antibodies were first discussed mainly from the point of view of human rcaginic components, and important papers were presented by K .J. Bloch (Boston), B. M. O oilvie and V. E. J ones (London), K. Ishizaka (Denver), and I. Broder (To ronto).Then there were four half-day sessions devoted to the chemical mediators, those released from cells and those derived from PMN-leucocytes, lymphocytes and platelets.In these sessions, the most significant (to the reviewer, at least) were contributions by A. G. Osler (New York), H. Z. Movat (Toronto), W. Vogt (Gottingen), M. E. Webster (Bethesda), and K. F. Austin (Boston) and their colleagues.The final part of the pro ceedings was concerned with humoral mediators generated in plasma and particularly with anaphy la toxin.An interesting account of the release of histamine from rat mast cells (by A. R. J ohnson and N. C. Moran, Atlanta) by antibody shows it to be selective as it is not generally accompanied by release of substances ranging in size from potassium ions to a protein such as lactic dehydrogenase or ATP, intracellular substances presumably located in cellular compartments other than the histamine-containing granules.The book is well produced and easy to read.It should be on the book shelves of all who work in the field of immunology.Naturally, in a subject which continues to advance rapidly now that newer techniques (such as radioimmune assay, gel filtration, and immunoelectrophoretic conversions) are freely available, some of the results of a meeting held in October 1968 are fast being modified by recent findings.It is apparent that even more rapid advances should come through comparable studies in animals.Furthermore unique pharmacological inhibitors of one stage of the anaphylactic reaction may provide new approaches to studying the tissue injury associated with immediate-type hypersensitivity.The success of the Canadian Symposium (like those now being organized in other parts of the world) was probably attributable to the multidisciplinary nature of the subject that was chosen, and for this reason the book is valuable as it records the ideas of both experi mentalists and clinicians.G. B. West, London
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.004 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.007 | 0.003 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.533 | 0.545 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".