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Record W4255836675 · doi:10.33263/briac92.849852

Oral delivery of proteins and peptides by mucoadhesive nanoparticles

2019· article· en· W4255836675 on OpenAlexaff
Simin Sharifi, Amir Samani, Elham Ahmadian, Aziz Eftekhari, Hossein Derakhshankhah, Samira Jafari, Masumeh Mokhtarpour, Sepideh Zununi Vahed, Sara Salatin, Solmaz Maleki Dizaj, Amir Abbas, Elham Neisani Samani, A Ahmadian, Hossein Eftekhari, Samira Derakhshankhah, Masumeh Jafari, Sepideh Mokhtarpour, Sara Zununi Vahed, Solmaz Salatin

Bibliographic record

VenueBiointerface Research in Applied Chemistry · 2019
Typearticle
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicAdvanced Drug Delivery Systems
Canadian institutionsWilliam Osler Health System
Fundersnot available
KeywordsOral cavityChemistryPeptideGastrointestinal tractOral routeEnzymeBiochemistryNanotechnologyComputational biologyBiologyMedicinePharmacologyMaterials scienceDentistry

Abstract

fetched live from OpenAlex

It seems that an ever growing tendency is necessary for the development of a strategy that can not only protect the peptides and proteins from degradation by the enzymes but also can improve their absorption without affecting biological activity. Delivery of peptides and proteins into the oral cavity remains an interesting approach, however for its availability some distinctive problems should be addressed. A wide variety of carriers have been investigated for delivery of peptides and proteins for the protection of their formulation and structure against the enzymatic environment of the gastrointestinal tract.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.002

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.131
GPT teacher head0.447
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations33
Published2019
Admission routes1
Has abstractyes

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