MétaCan
Menu
← Back to cohort
Record W4281287821 · doi:10.1038/s41598-022-12923-w

Author Correction: Optimizing the synthesis and purification of MS2 virus like particles

2022· erratum· en· W4281287821 on OpenAlexaff
Khadijeh Hashemi, Mohammad Mahdi Ghahramani Seno, Mohammad Reza Ahmadian, Bizhan Malaekeh‐Nikouei, Mohammad Reza Bassami, Hesam Dehghani, Amir Afkhami-Goli

Bibliographic record

VenueScientific Reports · 2022
Typeerratum
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicVirus-based gene therapy research
Canadian institutionsHospital for Sick Children
Fundersnot available
KeywordsComputer scienceVirusVirologyComputational biologyBiology

Abstract

fetched live from OpenAlex

The original version of this Article contained an error in Figure 4E, where thymine was used in place of uracil. The original Figure 4 and its accompanying legend appear below. Figure 4 VLPs produced in the NaNO3-Tris were more stable than VLPs produced in the NaNO3 solution. ( a ) Protein concentration evaluation of VLP suspension in two buffers. The amount of protein was reported as mg ml-1. ( b ) Number of VLPs in 1 ml VLP suspension according to the protein concentration. The values are from repeated measurements of samples through 12 months. ( c ) The scattered plot of VLP size in NaNO3 solution and NaNO3-Tris buffer (100 mM NaNO3 and pH: 8, for both of them). The size was analyzed 10 times in each sample and was shown as median with range. ( d ) Gel electrophoresis for RT-PCR fragments (99, 138, 177, and 216 bp); RT-PCR fragments of RNA extracted from VLPs in NaNO3-Tris (pH: 8)- left, and VLPs in NaNO3 (pH: 8)- right, after 3dyas, 3, 9, and 12 months. ( e ) The sequence of shRNA and four hairpins ( pac sites) was packed in MS2 VLPs. Primer locations were shown as Fw and Rev on the sequence. The stability of VLPs and their ability to protect the inner shRNA was checked by RNA extraction and RT-PCR. Full size image

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.023
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.032
Threshold uncertainty score0.106

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.023
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0020.001
Scholarly communication0.0020.001
Open science0.0020.001
Research integrity0.0030.006
Insufficient payload (model declined to judge)0.0320.020

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.292
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2022
Admission routes1
Has abstractno

Explore more

Same venueScientific Reports→Same topicVirus-based gene therapy research→French-language works237,207→